|
Symbol Name ID |
Dll4
delta like canonical Notch ligand 4 MGI:1859388 |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Portal vein thrombosis |
Right atrial enlargement |
Atrial septal defect |
Patent foramen ovale |
Ventricular septal defect |
Right ventricular hypertrophy |
Tetralogy of Fallot |
Bicuspid aortic valve |
Abnormal pulmonary valve morphology |
Hypoplastic left heart |
Pulmonary artery atresia |
Pulmonary artery stenosis |
Patent ductus arteriosus |
Arteriovenous malformation |
Aortic valve stenosis |
Pulmonic stenosis |
Hypertension |
Portal hypertension |
Pulmonary arterial hypertension |
Splenomegaly |
Hypersplenism |
Cavernous hemangioma |
Cutis marmorata |
| Disease(s) Associated with DLL4 | ||||||||||||||||||||||||
| Adams-Oliver syndrome |
| Mouse Phenotypes | abnormal blood vessel morphology |
abnormal artery morphology |
abnormal artery development |
abnormal dorsal aorta morphology |
abnormal umbilical artery morphology |
aorta stenosis |
abnormal internal carotid artery morphology |
abnormal capillary morphology |
abnormal retina vasculature morphology |
abnormal induced retina neovascularization |
abnormal placenta vasculature |
abnormal vascular development |
abnormal angiogenesis |
abnormal vascular regression |
abnormal vascular branching morphogenesis |
abnormal vein development |
abnormal cardinal vein morphology |
abnormal anterior cardinal vein morphology |
abnormal common cardinal vein morphology |
abnormal vitelline vasculature morphology |
absent vitelline blood vessels |
abnormal vascular smooth muscle morphology |
abnormal vein morphology |
arteriovenous malformation |
blood vessel atresia |
trabecula carnea hypoplasia |
abnormal cardiac outflow tract development |
abnormal sinus venosus morphology |
double outlet right ventricle |
overriding aortic valve |
abnormal heart atrium morphology |
ventricular septal defect |
abnormal pulmonary valve morphology |
abnormal heart ventricle morphology |
abnormal pericardial cavity morphology |
pericardial edema |
pericardial effusion |
poor circulation |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Dll4tm1Jrt/Dll4tm1Jrt | |||||||||||||||||||||||||||||||||||||||
| Dll4tm1Grid/Dll4+ | |||||||||||||||||||||||||||||||||||||||
| Dll4tm1Jrt/Dll4+ | |||||||||||||||||||||||||||||||||||||||
| Dll4tm1Nwg/Dll4+ | |||||||||||||||||||||||||||||||||||||||
| Dll4tm2.1Vlcg/Dll4tm2.1Vlcg Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ (conditional) |
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| Dll4tm1Frad/Dll4+ Isl1tm1(cre)Tmj/Isl1+ (conditional) |
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| Dll4tm2.1Vlcg/Dll4+ Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ (conditional) |
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| Dll4tm2.1Vlcg/Dll4+ Tg(Nanog-cre)#Vlcg/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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